MALAT1相关胞浆小RNA
MALAT1相关胞浆小RNA(英語:MALAT1-associated small cytoplasmic RNA,缩写mascRNA)是一種在细胞质中发现的非编码RNA,长约53–61nt,由MALAT1(一個长链非编码RNA)的3′端经核糖核酸酶P酶切割形成5′端,再由核糖核酸酶Z切割出3′端,最後由CCA tRNA核苷酸转移酶在3′端加上CCA三個鹼基後產生[1]。此RNA在人體許多組織中都有表現,在演化上保守,二级結構與tRNA(亦由核糖核酸酶P和Z前后切割產生)類似,都为三叶草形,但不會被胺醯化[1]。
MALAT1相關胞漿小RNA(mascRNA) | |
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预测的mascRNA的二级结构和保守序列 | |
识别符 | |
代号 | mascRNA-menRNA |
Rfam | RF01684 |
其他数据 | |
RNA类型 | Gene |
域 | Eukaryota |
另见
编辑参考文献
编辑- ^ 1.0 1.1 1.2 Wilusz JE, Freier SM, Spector DL. 3′ end processing of a long nuclear-retained noncoding RNA yields a tRNA-like cytoplasmic RNA.. Cell. 2008, 135 (5): 919–932. PMC 2722846 . PMID 19041754. doi:10.1016/j.cell.2008.10.012.
- ^ Lu X, Huang J, Wu S, Zheng Q, Liu P, Feng H; et al. The tRNA-like small noncoding RNA mascRNA promotes global protein translation.. EMBO Rep. 2020, 21 (12): e49684. PMC 7726780 . PMID 33073493. doi:10.15252/embr.201949684.
- ^ Xie SJ, Diao LT, Cai N, Zhang LT, Xiang S, Jia CC; et al. mascRNA and its parent lncRNA MALAT1 promote proliferation and metastasis of hepatocellular carcinoma cells by activating ERK/MAPK signaling pathway.. Cell Death Discov. 2021, 7 (1): 110. PMC 8128908 . PMID 34001866. doi:10.1038/s41420-021-00497-x.
- ^ Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL. MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 2009, 19 (3): 347–359. PMC 2661813 . PMID 19106332. doi:10.1101/gr.087775.108.