肌球蛋白轻链激酶
肌球蛋白轻链激酶（英語：Myosin light-chain kinase，MYLK 或 MLCK）是一类丝氨酸/苏氨酸特异性蛋白激酶，通过磷酸化来调节II型肌球蛋白的轻链[3]。
| 肌球蛋白輕多肽激酶，平滑肌 | |
|---|---|
| 識別 | |
| 符號 | MYLK |
| Entrez | 4638 |
| HUGO | 7590 |
| OMIM | 600922 |
| RefSeq | NM_053025 |
| UniProt | Q15746 |
| 其他資料 | |
| EC編號 | 2.7.11.18 |
| 基因座 | 3 qcen-q21 |
| myosin light-chain kinase 2, skeletal muscle | |
|---|---|
| |
| Crystal structure of the S. dubia centrin / human skeletal muscle myosin light-chain complex.[1] | |
| 識別 | |
| 符號 | MYLK2 |
| Entrez | 85366 |
| HUGO | 16243 |
| OMIM | 606566 |
| RefSeq | NM_033118 |
| UniProt | Q9H1R3 |
| 其他資料 | |
| 基因座 | 20 q13.31 |
| myosin light-chain kinase 3, cardiac | |
|---|---|
| 識別 | |
| 符號 | MYLK3 |
| Entrez | 91807 |
| HUGO | 29826 |
| OMIM | 612147 |
| RefSeq | NM_182493 |
| UniProt | Q32MK0 |
| 其他資料 | |
| 基因座 | 16 q11.2 |
| 人類肌球蛋白輕鏈激酶 | |
|---|---|
| |
| The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.[2] | |
| 識別 | |
| 符號 | MYLK4 |
| Entrez | 340156 |
| HUGO | 27972 |
| RefSeq | NM_001012418 |
| UniProt | Q86YV6 |
| 其他資料 | |
亚型
编辑现存四种MLCK亚型[4]主要分布于不同肌细胞：
功能
编辑另见
编辑参考文献
编辑- ^ RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex. （原始内容存档于2017-06-30）.
- ^ RCSB Protein Data Bank - Structure Summary for 2X4F - The Crystal Structure of the Human Myosin Light Chain Kinase Loc340156.. （原始内容存档于2017-06-30）.
- ^ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. PMID 11758800. doi:10.1080/152165401753366087.
- ^ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. PMID 12471243. doi:10.1126/science.1075762.
延伸阅读
编辑- Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Clayburgh DR, Rosen S, Witkowski ED; et al. A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.. J. Biol. Chem. 2005, 279 (53): 55506–13. PMC 1237105 . PMID 15507455. doi:10.1074/jbc.M408822200.
- Wang F, Graham WV, Wang Y; et al. Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.. Am. J. Pathol. 2005, 166 (2): 409–19. PMC 1237049 . PMID 15681825. doi:10.1016/S0002-9440(10)62264-X.
- Russo JM, Florian P, Shen L; et al. Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.. Gastroenterology. 2005, 128 (4): 987–1001. PMC 1237051 . PMID 15825080. doi:10.1053/j.gastro.2005.01.004.
- Shimizu S, Yoshida T, Wakamori M; et al. Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. PMC 1464317 . PMID 16284075. doi:10.1113/jphysiol.2005.097998.
- Kim MT, Kim BJ, Lee JH; et al. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol. 2006, 290 (4): C1031–40. PMID 16306123. doi:10.1152/ajpcell.00602.2004.
- Kimura K, Wakamatsu A, Suzuki Y; et al. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.. Genome Res. 2006, 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci. 2007, 119 (Pt 11): 2269–81. PMID 16723733. doi:10.1242/jcs.02926.
- Seguchi O, Takashima S, Yamazaki S; et al. A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.. J. Clin. Invest. 2007, 117 (10): 2812–24. PMC 1978424 . PMID 17885681. doi:10.1172/JCI30804.
外部链接
编辑
肌球蛋白轻链激酶引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。